HUNTSVILLE, Ala. — EGEN, Inc. today announced that it has recently initiated a Phase I clinical trial of its novel immunotherapy agent, EGEN-001, in combination with PEGylated liposomal Doxorubicin or Lipodox for the treatment of recurrent ovarian cancer. The EGEN-sponsored trial is conducted by a network of researchers led by Gynecologic Oncology Group (GOG) at member institutions under an agreement between the GOG and EGEN, Inc. Premal Thaker, M.D., M.S., of Washington University School of Medicine, is the Study Chair for the trial.
"We are pleased to have this trial begin as it advances the testing of our novel EGEN-001 product with an approved second-line treatment for platinum-resistant ovarian cancer," commented Khursheed Anwer, Ph.D., president and chief scientific officer for EGEN. "Long-term treatment with an immune modulating agent in conjunction with cytotoxic agents is a promising approach to combating difficult to treat cancers."
The product utilizes the Company's proprietary TheraPlas® delivery technology and is composed of interleukin-12 (IL-12) gene formulated with a biocompatible delivery polymer. IL-12 is a potent cytokine which works by enhancing the body's immune system against cancer and inhibiting tumor blood supply. EGEN-001 product is currently being examined as a single agent in a Phase II clinical trial for the treatment of platinum-resistant ovarian cancer and in combination with chemotherapeutic agents following cytoreductive surgery and HIPEC therapy in colorectal cancer.
Dr. Guy Caldwell, Ph.D. and Dr. Kim Caldwell, Ph.D., Molecular Biologists, Assistant Professors, Department of Biological Sciences
“I never set out to be a professor and researcher; I sort of stumbled into that job. However, I always wanted to know more about nature because I loved animals, rocks, planets, stars, fish, etc. So, in school I took a lot of science courses and along the way I just kept narrowing my focus as I found out what areas of science I liked.” —Dr. Kim Caldwell
“Fall in love with biology, chemistry, math and computer classes early. I use my degree every day. Biology–specimens/cell division; chemistry-mixing and usage of reagents in our protocols; math–measuring DNA; computers–capturing and karyotyping chromosomes.”
“I choose this career because I really enjoy the fast pace changes of science and genetics and I like to help people. I wanted a career that would allow me to be in healthcare but I was not interested in being a physician or nurse or working in a research laboratory setting.”
“I travel independently throughout the community to inspect food processing plants, hotels, restaurants, day care and nursing home food service facilities, jails, schools, night clubs and even body art facilities. Every day I am out meeting new people and seeing different things.”
“As a medical epidemiologist working at a state health department, I have investigated acute disease outbreaks; reviewed and analyzed data from reported, notifiable disease cases; and planned and implemented intervention measures to reduce the occurrence of preventable communicable diseases.”
“Computational biology is an exciting interdisciplinary field of research that integrates concepts from statistics, mathematics, computer science, and physics to solve problems in biology and biomedical research.”
“As a biochemical geneticist, my work specifically focuses on the diagnosis of inherited metabolic disorders, which typically afflict infants and young children, and often cause severe, even life threatening symptoms.”
“Did I choose the career or did the career choose me? That is an interesting question. I have always been interested in science, and grew up on a farm. So the marriage of science and agriculture was a natural for me.”