A gene has been associated with human kidney aging, according to researchers from Stanford University, the National Institute on Aging, the MedStar Research Institute, and the HudsonAlpha Institute for Biotechnology. In work published on October 16 in the open-access journal PLoS Genetics, the investigators, including HudsonAlpha Faculty Investigators Rick Myers and Devin Absher, claim that their approach can be applied to any phenotype of interest to help find other genetic associations.
Kidneys age at different rates, such that some people show little or no effects of kidney aging whereas others show rapid functional decline. Determining genetic factors associated with different rates of kidney aging contributes to the understanding of molecular mechanisms underlying the human aging process. Although family studies have shown that genes play a role in longevity, it has proven difficult to identify the specific genetic variants involved, until now.
Because data from both populations were combined in the kidney aging association analysis, the researchers stress that this finding needs to be replicated in additional populations. As more aging genes are discovered and confirmed, the particular genetic variants belonging to a person could one day be combined to better predict the aging trajectory of the kidney.