HudsonAlpha Journal Club

The HudsonAlpha Journal Club gives trainees at the Institute an opportunity to present and discuss publications relevant to their research areas. The meetings provide the trainees in HudsonAlpha labs valuable experience with science communication and presentations. Journal Club is hosted by HudsonAlpha faculty investigator Sara Cooper, PhD.

Upcoming Journal Club Meetings

Kimberly Hobbs

CRISPR-Cas9 epigenome editing enables high-throughput screening for functional regulatory elements in the human genome.

James Lawlor

Topic TBD

Brian Moyers

Topic TBD

Previous Paper Discussions

Kevin Bowling, May 3, 2017

Saleheen, Danish, Pradeep Natarajan, Irina M. Armean, Wei Zhao, Asif Rasheed, Sumeet A. Khetarpal, Hong-Hee Won et al. “Human knockouts and phenotypic analysis in a cohort with a high rate of consanguinity.” Nature 544, no. 7649 (2017): 235-239.

Jaimie Richards, April 19, 2017

Yusuf, Rafeek A., Deevakar Rogith, Shelly RA Hovick, Susan K. Peterson, Allison M. Burton‐Chase, Bryan M. Fellman, Yisheng Li, Carolyn McKinney, Elmer V. Bernstam, and Funda Meric‐Bernstam. “Attitudes toward molecular testing for personalized cancer therapy.” Cancer 121, no. 2 (2015): 243-250.

Megan Breitbach, April 5, 2017

Erikson, Galina A., Dale L. Bodian, Manuel Rueda, Bhuvan Molparia, Erick R. Scott, Ashley A. Scott-Van Zeeland, Sarah E. Topol et al. “Whole-genome sequencing of a healthy aging cohort.” Cell 165, no. 4 (2016): 1002-1011.

Michelle Amaral, March 15, 2017

Sambandan, S., Akbalik, G., Kochen, L., Rinne, J., Kahlstatt, J., Glock, C., … & Schuman, E. M. (2017). Activity-dependent spatially localized miRNA maturation in neuronal dendrites. Science, 355(6325), 634-637.

Emily Gordon, March 1, 2017

Verissimo, C. S., Overmeer, R. M., Ponsioen, B., Drost, J., Mertens, S., Verlaan-Klink, I., … & Bernards, R. (2016). Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening. eLife, 5, e18489.

Krysta Engel, February 15, 2017

Jagannathan, S., & Bradley, R. K. (2016). Translational plasticity facilitates the accumulation of nonsense genetic variants in the human population. Genome Research, 26(12), 1639-1650.

Nick Cochran, January 25, 2017

Chailangkarn, T., Trujillo, C. A., Freitas, B. C., Hrvoj-Mihic, B., Herai, R. H., Diana, X. Y., … & Stefanacci, L. (2016). A human neurodevelopmental model for Williams syndrome. Nature, 536(7616), 338-343.

Surya Chhetri, January 13, 2016

Domcke, S., Bardet, A. F., Ginno, P. A., Hartl, D., Burger, L., & Schübeler, D. (2015). Competition between DNA methylation and transcription factors determines binding of NRF1. Nature.

Drew Hardigan, December 7, 2016

Javierre, Biola M., Oliver S. Burren, Steven P. Wilder, Roman Kreuzhuber, Steven M. Hill, Sven Sewitz, Jonathan Cairns et al. “Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters.” Cell 167, no. 5 (2016): 1369-1384.

Brittany Lasseigne, November 16, 2016

Hause, R. J., Pritchard, C. C., Shendure, J., & Salipante, S. J. (2016). Classification and characterization of microsatellite instability across 18 cancer types. Nature Medicine.

Ryan Ramaker, November 2, 2016

Katainen, R., Dave, K., Pitkänen, E., Palin, K., Kivioja, T., Välimäki, N., … & Kondelin, J. (2015). CTCF/cohesin-binding sites are frequently mutated in cancer. Nature genetics, 47(7), 818-821.

Jaimie Richards, October 19, 2017

Ewing, A., Thompson, N., & Ricks-Santi, L. (2015). Strategies for enrollment of African Americans into cancer genetic studies. Journal of Cancer Education, 30(1), 108-115.

Keenan, T., Moy, B., Mroz, E. A., Ross, K., Niemierko, A., Rocco, J. W., … & Bardia, A. (2015). Comparison of the genomic landscape between primary breast cancer in African American versus white women and the association of racial differences with tumor recurrence. Journal of Clinical Oncology, JCO-2015.

Timley Watkins, October 5, 2016

Chew, W. L., Tabebordbar, M., Cheng, J. K., Mali, P., Wu, E. Y., Ng, A. H., … & Church, G. M. (2016). A multifunctional AAV-CRISPR-Cas9 and its host response. Nature Methods, 13(10), 868-874.

Matthew Neu, September 15, 2016

Krishnan, A., Zhang, R., Yao, V., Theesfeld, C. L., Wong, A. K., Tadych, A., … & Troyanskaya, O. G. (2016). Genome-wide prediction and functional characterization of the genetic basis of autism spectrum disorder. Nature Neuroscience.